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Description

In systemic in vivo research (animal models of wound healing, tissue regeneration) it is used by injection (subcutaneously, intraperitoneally) at doses typically 1 to 10 mg/kg daily for 2 to 6 weeks

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The 4-hydroxy metabolite was not mutagenic in a number of in vitro and in vivo assays

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By integrating both mechanistic and clinical evidence, this review aims to improve understanding of curcumins potential role and inform its future application in the management of DACD

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have demonstrated that HIF-1 promotes bone resorption mediated by osteoclasts (OCs), while angiopoietin-like 4 (ANGPTL4) compensates for HIF-1s inadequate stimulation of OC activity and promotes the proliferation and differentiation of osteoblasts (OBs) (138)

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